Stephan Kadauke | Associate Professor of Clinical Pathology and Lab Medicine
The Children's Hospital of Philadelphia

Dr. Stephan Kadauke is a physician-scientist whose work centers on translating cell and gene therapy platforms from early feasibility and risk assessment into first-in-human clinical implementation. He is Co-Director of the Cell Based Therapy Laboratory at Children’s Hospital of Philadelphia, where he oversees clinical manufacturing operations, regulatory strategy, and cross-program integration for more than thirty active cell therapy trials. These programs include CAR-T cells, autologous gene-modified hematopoietic stem cell therapies, and allogeneic stem cell transplantation. A core focus of Dr. Kadauke’s work is defining what preclinical and translational evidence is necessary, and sufficient, to responsibly advance novel therapies to patients within an academic medical center. He has led the clinical rollout of multiple new cell therapy platforms, including the implementation of a fully automated CAR-T manufacturing program. His efforts emphasize close coordination across clinical, manufacturing, informatics, and regulatory teams, with deliberate prioritization of studies that directly address safety, feasibility, and regulatory decision points.