Dr Audray Harris | Investigator
National Institutes of Health

Dr Audray Harris, Investigator, National Institutes of Health

Dr. Harris is a Tenure-Track Investigator and Chief of the Structural Informatics Unit in the Laboratory of Infectious Diseases at the National Institute of Allergy and Infectious Diseases. His laboratory studies the molecular structure of viral complexes that function in activities such as virus entry, assembly and replication. Many of these viral complexes are also antigens used in viral vaccines and targets for antivirals. His laboratory focuses on viral structures and assembly with a goal of optimizing the design of immunogens for influenza vaccine development. Recent findings include identification of the structural basis for oligomerization and polymorphism of recombinant influenza hemagglutinin complexes in a licensed influenza vaccine, and the structure-guided design and characterization of protein nanoparticles that display conserved influenza epitopes and elicit neutralizing antibodies to influenza viruses.  A major goal of the Unit is to provide a structural basis for the design and development of a universal influenza vaccine.  He is a member of the Biophysical Society, American Society for Microbiology and Chesapeake Society for Microscopy.

Appearances:



Agenda Day 1 @ 5:15

Using 3D Cryo-electron microscopy technology to determine the structures of vaccine nanoparticles to enable better vaccine design

  • Using state of the art structural biology techniques to design nanoparticles that display conserved epitopes; influenza case study
  • The importance of conformational state in B-cell activation
  • Potential for use in other infectious diseases and immunotherapy
  • The future of immunogen design to elicit the required antibodies and the characterisation of therapeutic antibodies to boost immune response

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