Dr Samir Khleif | Director of Immunotherapy and Immune Oncology Program
Georgia Regents University Cancer Center

Dr Samir Khleif, Director of Immunotherapy and Immune Oncology Program, Georgia Regents University Cancer Center

Dr. Khleif currently serves as the Director of the State of Georgia Cancer Center, Georgia Regents University Cancer Center and the Cancer Service Line. He is a Georgia Research Alliance Distinguished Cancer Scientist and Clinician and holds a professorship in Medicine, Biochemistry and Molecular Biology, and Graduate Studies at Georgia Regents University. Dr. Khleif’s research program focuses on the molecular mechanisms of the interaction between cancer and the immune system. He received his medical degree at the University of Jordan, Amman Jordan. He completed his residency in Internal Medicine at the Medical College of Ohio and his fellowship in Medical Oncology at the National Cancer Institute (NCI) in Bethesda, Maryland. His laboratory works on understanding the mechanisms of cancer-induced immune suppression, and utilizing this knowledge for the development of novel immune therapeutics and vaccines against cancer. His team designed and conducted some of the first cancer vaccine clinical trials directed against specific genetic changes in cancer cells. Currently, his research group works on strategies to target immune suppressive mechanisms of T regulatory cells and co-inhibitory molecules such as PD1 and CTLA4; developing novel strategies to manipulate such pathways to selectively block cancer immune suppression; and developing novel approaches in clinical trials for immune therapy in immune combination approaches to enhance anti-tumor effects.

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