Dr Nir Hacohen | Director of the Center for Cancer Immunology and Co-Director of the Center for Cell Circuits
Broad Institute and Massachusetts General Hospital | United States

Dr Nir Hacohen, Director of the Center for Cancer Immunology and Co-Director of the Center for Cell Circuits, Broad Institute and Massachusetts General Hospital

Dr. Hacohen is the Director of the Center for Cancer Immunology at Massachusetts General Hospital, and Co-Director of the Center for Cell Circuits at the Broad Institute.
Dr. Hacohen leads a group of immunologists, geneticists, biochemists, technologists and computational biologists to develop unbiased strategies to dissect immune response in health and disease, with an emphasis on the innate immune system and personal medicine. Three major questions are addressed. How are immune responses against cancer initiated, maintained and evaded? What are the immune circuits that sense and control pathogens, such as viruses and bacteria? How does immunity against the body develop in autoimmunity? The group also applies unbiased analytical strategies to develop real-world therapeutics, with completed and ongoing human clinical trials of personal neoantigen vaccines based on a computational analysis of the personal tumor genome (with Dr. Catherine Wu).
 

Appearances:



DC Co-conference Day 2 April 4 @ 5:10

Panel Discussion: Tumor neoantigEn SeLection Alliance (TESLA) – discovering the keys to developing personalized cancer vaccines

  • Accurately identifying neo-epitopes
    • What is the diversity of neo-epitope predictions from different groups?
    • How well did these predictions perform in terms of patient sample analysis?
    • Can we identify key parameters that improve the ability to predict neo-epitopes?
  • How do we convert this data into the creation of personalized cancer vaccines?
    • Merits of different vaccines platforms

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