Dr. Barney Graham is an immunologist, virologist, and clinical trials physician whose primary interests are viral pathogenesis, immunity, and vaccine development. His work is focused on HIV, respiratory syncytial virus (RSV), and emerging viral diseases. After graduating from Rice University, he obtained his MD from the University of Kansas School of Medicine in 1979. He then completed residency and two chief residencies in Internal Medicine, a fellowship in Infectious Diseases, and a PhD in Microbiology & Immunology at Vanderbilt University School of Medicine, where he rose to the rank of Professor of Medicine with a joint appointment in the Department of Microbiology & Immunology. In 2000 he became one of the founding investigators for the NIAID Vaccine Research Center at NIH where he is now the Deputy Director and Chief of the Viral Pathogenesis Laboratory. He is a member of the American Society for Clinical Investigation and the American Association of Physicians, and a Fellow of the Infectious Disease Society of America and the American Academy of Microbiology. He has authored more than 250 scientific publications and has been on editorial boards for the Journal of Biological Chemistry, Journal of Virology, Journal of Infectious Diseases, and Journal of AIDS. His laboratory investigates basic mechanisms by which T cells affect viral clearance and immunopathology, and how T cell function can be modulated by vaccination. RSV vaccine development, exploring the structure and function of the RSV F glycoprotein, and defining mechanisms of antibody-mediated RSV neutralization are projects of particular interest.