Jeffrey D. Marrazzo is the co-founder and chief executive officer of Spark Therapeutics, Inc. (NASDAQ: ONCE) and serves on the board of directors. Jeff has led the creation and growth of Spark from a research center within The Children's Hospital of Philadelphia to a publicly-traded, integrated gene therapy company developing one-time, life-altering treatments to transform the lives of patients and re-imagine the treatment of debilitating diseases. Under Jeff's leadership, Spark has raised more than $265 million in capital, established a global collaboration with Pfizer for the development and commercialization of a gene therapy for hemophilia B, recruited some of the world's pioneers in gene therapy together with a team of biotechnology industry executives, and advanced the company's lead product candidate for the treatment of rare, blinding conditions to a fully-enrolled Phase 3 clinical trial. Jeff is an experienced entrepreneur dedicated to curing disease through precision medicine, having helped build and sell the first genetic testing benefit management and pharmacogenomics medicines company to CVS Caremark. Previously, Jeff served as an advisor to former Pennsylvania Governor Edward G. Rendell. Jeff received his B.A. in economics, magna cum laude, and B.S.E. in systems science and engineering, magna cum laude, from the University of Pennsylvania, and holds a dual M.B.A. / M.P.A. from The Wharton School and Harvard University, a program which he founded.