Wolfgang W Leitner is the Chief of the Innate Immunity Section, NIAID/NIH. He was involved in deciphering the mechanisms underlying the regeneration of splenic autotransplants and developed the first nucleic acid vaccine for P. berghei malaria. While establishing a replicase-based DNA vaccine for the treatment of melanoma, he uncovered the immune mechanism underlying the superior immunogenicity of aphavirus-based nucleic acid vaccines. He has authored more than 70 papers in the areas of vaccine research, basic immunology and cancer therapy. He joined the NIAID Extramural Program as a Program Officer in 2008 and oversees the innate immunity portfolio, including vaccine adjuvant research.