Dr Raphael Simon | Assistant Professor of Medicine
University of Maryland School of Medicine

Dr Raphael Simon, Assistant Professor of Medicine, University of Maryland School of Medicine

The goal of Dr. Simon’s research is the development of vaccines to prevent invasive infections with bacterial pathogens, including Salmonella enterica and Klebsiella pneumoniae. A main area of focus is the development of polysaccharide:protein glycoconjugate vaccines based on the O polysaccharide (OPS) of lipopolysaccharide with novel carrier proteins. This involves the development of novel purification techniques to obtain protein and polysaccharide vaccine antigens, synthesis and biochemical characterization of vaccine constructs, assessment of immunogenicity and vaccine protective efficacy, and biological analyses of antibody function in-vitro.

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