William Barnett is the Chief Research Informatics Officer (CRIO) for the Indiana Clinical and Translational Sciences Institute (CTSI) and the Regenstrief Institute. In that role, he has a dual integrated mission. First, to provide, integrate, and advance biomedical informatics services, including process-based services like the clinical trials, data management, and web portal services provided by the Indiana CTSI, and to lead the research data and analytics services. In that he provides strategic leadership for applied informatics for the Indiana CTSI and Regenstrief. Second, to engage in informatics research to develop and apply innovative approaches to advancing healthcare research as a Regenstrief Investigator. His current focus is on secondary use of medical records, precision health informatics, and team science at national scales. He is infrastructure lead for the Indiana University Precision Health Initiative, and is a Visiting Associate Research Professor in the Department of Medical and Molecular Genetics at the IU School of Medicine.