4-Antibody

4-Antibody is a biopharmaceutical company with a powerful fully-human antibody drug-discovery technology platform, which is generating an emerging pipeline of antibody therapeutics. The proprietary discovery engine is the in-vitro Retrocyte Display® technology, a fast and highly efficient source of antibody drug candidates. Retrocyte Display® generates high quality therapeutic antibody drug candidates quickly using a rapid, high-throughput, flow cytometry approach incorporating full-length IgG format human antibody libraries expressed in mammalian B cells (the cell designed by nature for optimal antibody display).
4-Antibody provides access to its technologies to pharmaceutical R&D collaborators and is also generating an in-house pipeline of antibody drugs. The Company’s lead development product is an anti-cytomegalovirus antibody drug.
4-Antibody is a private company with strong, commercially-experienced leadership located in Basel, Switzerland and Jena, Germany.
The 4-Antibody core technology platform provides an integrated solution for discovering ‘better-behaved,’ fully human, development-ready lead antibodies and combines the speed and diversity of an in vitro discovery platform with the selectivity of an in vivo system. The in vitro Retrocyte Display® technology utilizes human antibody libraries expressed as full-length IgG in immortalized pre-B cells to screen against antigen targets using a combination of high throughput, multi-parameter magnetic and fluorescence-based cell sorting for antigen-reactive clones. Novel antibody candidates for soluble as well as membrane-bound antigens can be identified.