Optimised cell culture development for pharma, biotech, CMOs and media providers
Dr Hervé Broly | Vice President Biotech Process Sciences Merck Serono
Starting with an Engineering degree coupled with a doctorate in Physiology, Hervé Broly developed the manufacture of monoclonal antibodies for diagnostic reagent and therapeutical use at the Regional Blood Transfusion Center of Lille (France) from 1982 to 1991 and then at a subsidiary of Serono located in Bordeaux (France) from 1991 to 2003.
From November 2003 to October 2006, Hervé Broly has been working as Program Director for the development of a recombinant protein for therapeutic use (atacicept) at Serono Corporate (Geneva, Switzerland) and then from November 2006 as Vice-President, Head of Biotech Process Sciences and Center of Expertise Biotech Bulk Manufacturing for Merck-Serono (Vevey, Switzerland). Current research focus relates to the improvement of the Merck Serono technology platform for the manufacture of McAbs and Fc-fusion recombinant proteins, to applying Quality by Design approach for the manufacture of bulk drug substance, and to the development of novel approaches for downstream processing.
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Appearances at this years' conference:
DAY 1 - Tuesday 28th February 2012
@ 09.10
Applying QbD concept for the manufacture of biotech drug substance: is the design space dependent or independent of scale?
Merck Serono has developed the concept of Global Multi-step Design Space
The Design Space is almost developed on the basis of DoE experiments done at small-scale
Small-scale models were qualified by comparison with large-scale data obtained at central points
Are the limits of the Design Space still valid at manufacturing scale?
› Dr Hervé Broly, Vice President Biotech Process Sciences, Merck Serono
@ 16.50
Panel discussion: evaluating the opportunities to develop cell culture bio-production
Given the need to produce biologics faster and cheaper, what strategies are the industry looking to in the future to achieve this?
Can understanding the benefits and limitations of different cell culture procedures aid in achieving the desired product in the shortest time with maximum yields?
Evaluating current technologies and methodologies which could deliver an optimized end-to-end production systems
› Dr Hervé Broly, Vice President Biotech Process Sciences, Merck Serono